ISSN - | E-ISSN -2822-2288
Eurasian Journal of Medical Advances
The Role of Sirtuin 2 in Chemotherapeutic Resistance [EJMA]
EJMA. Ahead of Print: EJMA-43531 | DOI: 10.14744/ejma.2022.43531

The Role of Sirtuin 2 in Chemotherapeutic Resistance

Özlem Türelik1, Damla Gül Fındık2
1Department of Pathology, Bilecik Training and Research Hospital, Bilecik, Turkey
2Deparment of Histology and Embryology, Bilecik Şeyh Edebali University Faculty of Medicine, Bilecik, Turkey

The lack of effective chemotherapy agents and the development of multi-drug resistance in advanced cancers are major encountered issues during treatment phase. The resistance of cancer cells against chemotherapeutic agents may occur as a result of different mechanisms. The identification of molecular pathways involved in drug resistance will yield the occurrence of alternative therapeutic strategies. Sirtuin 2 is one of the NAD-dependent deacetylases. It is involved in carcinogenesis to fulfill oncogenic and tumor-suppressing functions. Therefore, Sirtuin 2 modulation becomes a promising approach in cancer treatments. A better understanding of Sirtuin 2 related pathways is required to provide guidance to alternative cancer treatments. There are several studies about the effects of Sirtuin 2 on various types of cancers in recent years. Within the scope of this review, it is aimed to present the molecular pathways of Sirtuin 2 and its association with chemotherapeutic resistance.

Keywords: Drug Resistance, Neoplasms, Sirtuin 2

Corresponding Author: Damla Gül Fındık, Türkiye
Manuscript Language: English