Objectives: This study investigated the role of vitamin D in Graves' disease and autoimmune thyroid disease and examined the relationship between vitamin D levels and thyroid ophthalmopathy, inflammation, body mass, and thyroid autoantibodies.
Methods: The study included 80 participants: 40 active Graves' disease patients before treatment, 20 patients with euthyroid autoimmune thyroid disease, and 20 healthy individuals. All Graves' disease patients were evaluated for ophthalmopathy. Measurements included 25(OH)D, high-sensitivity CRP, erythrocyte sedimentation rate, fibrinogen, and anthropometric assessments. Thyroid function tests and autoantibodies were evaluated in the autoimmune thyroid disease group.
Results: Vitamin D levels were significantly lower in Graves' disease and autoimmune thyroid disorder patients compared to healthy controls. Lower vitamin D correlated with higher thyroid receptor and anti-thyroid peroxidase antibodies. Patients with thyroid ophthalmopathy had even lower vitamin D levels. Vitamin D deficiency was associated with inflammation and higher body mass index.
Conclusion: Lower vitamin D levels were linked to Graves' disease, autoimmune thyroid disorders, and thyroid ophthalmopathy. Vitamin D deficiency was also associated with increased inflammation in these conditions, suggesting a potential role for vitamin D in the pathogenesis of autoimmune thyroid disorders, particularly thyroid ophthalmopathy.

Objectives: Many factors considered to influence prognosis in gastric cancers have been investigated. In this study, we aimed to present the demographic characteristics of gastric cancer patients followed in the medical oncology unit, to investigate the effects on prognosis of MCV values measured at diagnosis, after surgery, and after chemotherapy, and to evaluate the effect on prognosis among C-ERB B2–positive patients.
Methods: 248 patients who presented to and were followed by the İstanbul Eğitim ve Araştırma Hastanesi Medical Oncology Unit between 2010 and 2015 were examined retrospectively using the hospital automation system and the oncology unit file archive.
Results: A total of 248 patients diagnosed with gastric cancer (169 male, 79 female) were included. Among 50 stage 4 patients in whom C-ERB B2 was assessed, 8% (n=4) were 2+, 34% (n=17) were 3+, and 58% (n=29) were negative. Overall survival rates were 62.7% at 1 year, 44.6% at 2 years, 37.7% at 3 years, 30.7% at 4 years, and 28.8% at 5 years. On quantitative analysis of MCV values at diagnosis and after treatment, having MCV > 100 fL at any time point was not statistically significant in terms of prognosis. Likewise, a post-/pre-treatment MCV ratio >1.1 was not statistically significant. These parameters were also evaluated in the C-ERB B2–positive population and no significant difference was detected. Conclusion: Although changes in MCV values did not show a significant effect on prognosis, it was considered that increasing the patient population might yield statistical significance.

Objectives: To evaluate the prognostic significance of baseline neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in newly diagnosed multiple myeloma (MM).
Methods: We retrospectively analyzed 327 MM patients (2012–2018) from a single tertiary center. Baseline clinical, hematologic, and biochemical data were collected. NLR and PLR were calculated. OS was estimated via Kaplan–Meier and Cox regression. ROC analysis determined an NLR cutoff.
Results: Median OS was 46.1 months; 1-, 2-, and 5-year OS rates were 77.4%, 64.5%, and 44.0%, respectively. Each one-unit increase in NLR raised the risk of death by 9.3% (HR 1.093; p=0.015). NLR correlated with poorer OS in ISS stage II, hemoglobin <10 g/dL, ≥40% bone marrow plasma cell infiltration, and calcium ≥11 mg/dL. PLR showed no association with OS (p=0.957). ROC analysis identified an NLR cutoff of 1.7 (AUC 0.584).
Conclusion: Higher baseline NLR is associated with worse survival and adverse MM features but is insufficient as a standalone marker alongside ISS/R-ISS. PLR lacks prognostic value.