Prenylated flavonoids are one of the main active ingredients of Sophora species which have significant biological properties. Kuraridin, is a naturally occurring flavonoid in the roots of Sophora flavescens and possesses glycosidase inhibition, antibacterial, diacylglycerol acyltransferase, and tyrosinase inhibition activities. The present study summarized the scientific progress on the medical importance and pharmacological activity of kuraridin. Present review investigated the scientific research evidence of kuraridin available on various scientific databases such as PubMed, Springer, Google, Google Scholar, and Science Direct using the terms kuraridin, herbal medicine, Sophora flavescens and phytochemical. Present review described the medicinal importance and pharmacological activities of kuraridin in medicine. Analysis of scientific data signified the therapeutic potential of kuraridin against reovirus, gastric adenocarcinoma, tyrosine phosphatase 1B, antioxidant, BACE1 and cholinesterases, diacylglycerol acyltransferase, aldose reductase, inflammatory response, microorganism, enzymes and BKCa channel. Further present review also described the metabolomics and pharmacokinetic properties of kuraridin. Present review highlighted the biological potential of kuraridin in medicine.

Tunisia continues to experience tuberculosis at an intermediate level of endemicity. Isoniazid (INH) is a critical element in TB therapy. INH metabolism involves, mainly, the arylamine N-acetyltransferase 2 (NAT2) enzyme which is subject to genetic polymorphism. The determination of NAT2 acetylation profiles is highly recommended for dose adjustment and predicting side effects in tuberculosis patients. Traditionally, acetylator status has been assessed through phenotyping tests. Recently, faster and simpler genetic methods have been proposed as an alternative for use in clinical practice. This work provides a comprehensive review of main NAT2 phenotyping and genotyping results based on Tunisian experiences. In Tunisia, several studies have demonstrated the predominance of slow acetylator (SA) genotypes and phenotypes with the NAT2*5, being the most prelevant. When comparing acetylation phenotype with NAT2 genotype, a concordance value of 75% was observed. The choice of method for determining NAT2 acetylation profile primarily depends on the laboratory's technical capabilities and expertise. Prospective clinical trials are essential to further evaluate the benefits of NAT2 genotyping specifically within the Tunisian population.

Prostate cancer is a common tumor and is mainly found in the prostate tissue. Prostate cancer was the second most frequent cancer after lung cancer, and in 2020 it was the fifth cause of cancer in men around the world. Phytochemicals are natural compounds found in many types of medicinal plants, vegetables, and fruits. The aim of this review is to collect and analyze scientific information on phytochemicals with potential on prostate cancer and to highlight their therapeutic role in the treatment of prostate cancer with their underlying molecular mechanisms of action. In this study, we searched the PubMed, Google Scholar, Google, and Scopus databases to gather scientific information about phytochemicals with medicinal properties for prostate cancer using the terms prostate cancer, phytochemical, herbal medicine, medicine, and biological activity. The scientific analysis of the data in this review has shown that the medicinal importance of auriculasin, calycopterin, crebanine, denbinobin, irigenin, isolinderalactone, neobavaisoflavone, nodakenin, obacunone, pachypodol and tectochrysin are medically important due to their antiproliferative activity against cancer of the prostate. However, analysis of scientific data has also revealed other molecular mechanisms in medicine related to its effectiveness on prostate cancer. The scientific data in this review revealed the anticancer effects of a large number of phytochemicals in medicine against prostate cancer.

Objectives: The main purpose of the study is to determine the prognostic factors by retrospectively evaluating the clinical data of patients with pancreatic cancer.
Methods: The patients diagnosed with pancreatic adenocarcinoma (132) were analyzed retrospectively. Age, gender, blood group, tumour localisation, tumour stage (TNM classification), postoperative chemotherapy, postoperative radiotherapy status, progression-free survival and survival time as prognostic factors were evaluated. Women and men, tumours located in the head versus in the trunk and tail regions, received chemotherapy and/or radiotherapy versus those who didn't, patients in stage 2, patients with stage 3, stage 4, "A", "B", "O" blood groups were compared with each other and subgroup analysis was performed.
Results: In our study, 59.8% were male and 40.2% were female. Progression-free survival and survival times of patients with stage 2 cancer were found to be significantly longer then patients with stage 3 and 4 (p<0.01). Among stage 2 and 3 patients, 45 (38.6%) patients, 26 patients with stage 4 (19.6%) received chemotherapy, and 9 patients (6.81%) received chemotherapy and radiotherapy concurrently. Tumour was most common in the head side [(70.5%)]. Progression-free survival and survival of tumour localisation, receiving chemotherapy, and tumour stage was found to affect the duration of the study statistically significantly (p<0.001).
Conclusion: It was determined that chemotherapy and stage affected progression-free survival and survival times with statistical significance. Ca 19-9 and CEA values can be used in the follow-up of patients with pancreatic cancer. EUS is usefull at pancreas cancer diagnosıs and staging.

Objectives: This study aims to investigate the gene expression in breast cancer (BC) in response to radiation therapy using GEO2R analysis of datasets from the Gene Expression Omnibus database.
Methods: The data used in the research was obtained from the GEO of the GSE 59732 and GSE 59734 gene expression datasets. These datasets included various breast cancer treated with radiation therapy. DEGs (Differentially expressed genes) were identified using GEO2R of p-value less than 0.05 and a log FC threshold of 1.2. STRING was used to generate PPI (protein-protein interaction) networks, while Cytoscape software was used to identify important hub genes. The Enrichr tool was used to analyze Gene Ontology and KEGG pathway and network analyst tool was used to study gene-disease association.
Results: A total of 61 upregulated DEGs common in both datasets were observed in the study. Gene ontology analysis revealed that biological processes mostly enriched in regulation of peptidyl-tyrosin phosphorylation, cellular components mainly enriched in phosphatase binding. Proteoglycans in cancer found in both KEGG pathway and gene-disease association pathways.
Conclusion: The study identified DEGs in breast cancer in response to radiation therapy. Key hub genes, particularly EGFR and MAPK3, were linked to many cancer-related pathways including breast cancer.

Objectives: Mantle cell lymphoma (MCL) is one of the lymphoma subtypes that accounts for approximately 6% of Non-Hodgkin's lymphomas. In this study, we aimed to investigate the relationship between AMC at diagnosis and overall and disease-free survival in addition to other prognostic factors of the MCL patients.
Methods: Clinical, laboratory, and demographic data of 23 MCL patients were analyzed retrospectively who underwent treatment in the Department of Haematology at Istanbul University Faculty of Medicine between January 2006 and September 2014. Relationship with AMC at diagnosis and overall, disease-free survival was assessed and compared with other prognostic factors.
Results: The mean age of patients was 61.56±10.99. The median overall and disease-free survival were 61±2.1 and 44±4.3 months, respectively. There was no statistically significant relationship between AMC at diagnosis and overall (0.75) or disease-free (p=0.06) survival. The overall and disease-free survival was not statistically significant between the patient groups with absolute monocyte count >0.5x109/l and ≤0.5x109/l. However, we found a moderate correlation between LDH and absolute monocyte count at diagnosis (r=0.499; p=0.015).
Conclusion: The correlation between LDH levels and absolute monocyte count at diagnosis suggests a relation between these two parameters and prognosis.

Objectives: Nursing is one of the most stressful professions, and nurses need to have a work-life balance. This article assesses the job stress of nurses and identifies ways to improve the work-life balance.
Methods: A study was conducted on nurses working in hospitals of Ferozepur, Punjab, with the help of a demographic sheet and a structured questionnaire. All nurses not on long leave and willing to participate in the study were included in the study group.
Results: 50% of the nurses felt more pressurized due to family responsibilities, and their career development had slowed down. Most of them thought that their job left less time for their kids and husbands. 70% of them found it difficult to manage their household and office work if they had small kids. In case of conflict between household work and office work, 40% of nurses gave preference to household work.
Conclusion: Provision of childcare facilities, flexible working hours, adequate childcare leave, establishment of work-life balance cells, and formulationof human resource/leave policies can help achieve an optimum work-life balance amongst nurses, increase productivity at work and reduce attrition rate.

Objectives: The aim of this study was to investigate monoclonal gammopathy of undetermined significance (MGUS) in patients with renal cell carcinoma (RCC) and compare to healthy individuals.
Methods: This was a case-control study conducted between July 2022 and December 2022 including 68 patients with RCC and 47 healthy controls.
Results: The median age of control group was 67 (51-75) years and that of the RCC group was 59 (51-69.5) (p=0.039). Sex distributions were similar in the two groups. RCC disease duration was 24 (12-60) months. The albumin, calcium, hemoglobin, hematocrit levels, and lymphocyte (p<0.001 for all) and platelet counts (p=0.017) were significantly higher in the RCC group compared to controls. There was no significant difference between the groups in terms of the number of the patients with MGUS (p=0.512), monoclonal band positivity (p=0.512), abnormal bands positivity (p=0.080) and median gammaglobulin level (p=0.774).
Conclusion: The present study shows no evidence for increased MGUS incidence in patients with RCC; however, more comprehensive studies are required to clarify these findings in different populations and determine the potential roles of other factors in the relationship between RCC and MGUS.