Therapeutic Effectiveness of Hernandezine in Medicine for the Treatment of Cancer and other Human Complications: A Biologically active Bisbenzylisoquinoline Alkaloid from Nature
Dinesh Kumar Patel, Kanika PatelDepartment of Pharmaceutical Sciences, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj, Uttar Pradesh, IndiaAlkaloids are widely distributed in nature, especially in plants, animals, microorganisms and marine organisms. Hernandezine is a biologically active bisbenzylisoquinoline class alkaloid found to be present in different species of Thalictrum. The present review describes the biological potential and therapeutic effectiveness of hernandezine in medicine for the treatment of human disorders and associated secondary complications. The aim of the present paper is to collect all the scientific data of hernandezine from different scientific databases, including Scopus, Science Direct, Google, PubMed and Google Scholar and analyzed in the present paper in order to know the therapeutic potential of hernandezine in medicine. Present paper mainly focus on the pharmacological activities of hernandezine, however, pharmacokinetic data of hernandezine has also been described in the present review. Present review scientific data revealed the biological significance of hernandezine in medicine for the treatment of human disorders and associated secondary complications. Present review scientific data describe the medicinal importance of hernandezine through its therapeutic effectiveness on pancreatic cancer, hepatocellular carcinoma, type 2 diabetes, melanoma, colon cancer, glioma cells, acetylcholine receptor, hair cells, Ca2+ release, multidrug-resistance, permeabilization and TNF-α production. However, immunosuppressive potential and pharmacokinetic parameters of hernandezine were also described in the present work in order to know the different molecular mechanism of hernandezine. Present review also described the different molecular mechanisms of hernandezine. However, detailed preclinical and clinical scientific investigation is utmost important in the scientific fields in order to claim its therapeutic application in human disorders and associated secondary complications.
Keywords: Hernandezine, medicine, pancreatic cancer, hepatocellular carcinoma, type 2 diabetes, melanoma, colon cancer, glioma, acetylcholine receptor, hair cells, Ca2+ release, multidrug-resistance, immunosuppressive effect, pharmacokineticManuscript Language: English
