Article
Open Access
Volume 5 · Issue 2 · 2025
pp. 55–58
Paroxysmal Nocturnal Hemoglobinuria Associated Myelodysplastic Syndrome and Aplastic Anemia: A Single Center Experience
Sena Ece Davarcı1, İlhami Berber2, Aysun Toraman3, Mine Miskioğlu4, Tahir Buran5, Fevzi Altuntaş6, İsmet Aydoğdu7
1
1Department of Medical Oncology, Afyonkarahisar University of Health and Sciences, Afyonkarahisar, Türkiye
2
2Department of Hematology, Inonu University, Malatya, Türkiye
3
3Department of Nephrology, Manisa Celal Bayar University, Manisa, Türkiye
4
Department of Hematology, Manisa Celal Bayar University, Manisa, Türkiye
5
Department of Gastroenterology, Manisa Celal Bayar University, Manisa, Türkiye
6
Department of Hematology, Health Sciences University Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, Türkiye
7
Department of Hematology, Private İzmir Kent Hospital, İzmir, Türkiye
Abstract
Objectives: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare disease that could accompany aplastic anemia (AA) and myelodysplastic syndrome (MDS). In this study, we wanted to share our experiences about PNH clone positivity rates and the clinical effects in patients who were being followed up with diagnoses of AA and MDS.
Methods: We investigated 30 people in our study, 22 of whom had MDS and 8 of whom had AA. The PNH scan was carried out using the FLAER method, which is considered the gold standard today.
Results: PNH clone positivity rates were 4.5% in MDS and 62.5% in AA. Two of the patients initiated eculizumab treatment.
Conclusion: It is important to detect a PNH clone because of its effect on the course of other bone marrow diseases, especially AA and MDS.
Methods: We investigated 30 people in our study, 22 of whom had MDS and 8 of whom had AA. The PNH scan was carried out using the FLAER method, which is considered the gold standard today.
Results: PNH clone positivity rates were 4.5% in MDS and 62.5% in AA. Two of the patients initiated eculizumab treatment.
Conclusion: It is important to detect a PNH clone because of its effect on the course of other bone marrow diseases, especially AA and MDS.
Keywords: Complement system, Paroxysmal nocturnal hemoglobinuria, Thrombosis
