Unlocking the Biological Importance and Therapeutic Insights of Kuraridin: A Bioactive Prenylated Flavonoid from the Genus Sophora

Prenylated flavonoids are one of the main active ingredients of Sophora species which have significant biological properties. Kuraridin, is a naturally occurring flavonoid in the roots of Sophora flavescens and possesses glycosidase inhibition, antibacterial, diacylglycerol acyltransferase, and tyrosinase inhibition activities. The present study summarized the scientific progress on the medical importance and pharmacological activity of kuraridin. Present review investigated the scientific research evidence of kuraridin available on various scientific databases such as PubMed, Springer, Google, Google Scholar, and Science Direct using the terms kuraridin, herbal medicine, Sophora flavescens and phytochemical. Present review described the medicinal importance and pharmacological activities of kuraridin in medicine. Analysis of scientific data signified the therapeutic potential of kuraridin against reovirus, gastric adenocarcinoma, tyrosine phosphatase 1B, antioxidant, BACE1 and cholinesterases, diacylglycerol acyltransferase, aldose reductase, inflammatory response, microorganism, enzymes and BKCa channel. Further present review also described the metabolomics and pharmacokinetic properties of kuraridin. Present review highlighted the biological potential of kuraridin in medicine.

Keywords: Kuraridin, medicine, Sophora flavescens, pharmacological, analytical, phytochemical