Prognostic Value of Absolute Monocyte Count in Patients with Mantle Cell Lymphoma

Objectives: Mantle cell lymphoma (MCL) is one of the lymphoma subtypes that accounts for approximately 6% of Non-Hodgkin's lymphomas. In this study, we aimed to investigate the relationship between AMC at diagnosis and overall and disease-free survival in addition to other prognostic factors of the MCL patients.
Methods: Clinical, laboratory, and demographic data of 23 MCL patients were analyzed retrospectively who underwent treatment in the Department of Haematology at Istanbul University Faculty of Medicine between January 2006 and September 2014. Relationship with AMC at diagnosis and overall, disease-free survival was assessed and compared with other prognostic factors.
Results: The mean age of patients was 61.56±10.99. The median overall and disease-free survival were 61±2.1 and 44±4.3 months, respectively. There was no statistically significant relationship between AMC at diagnosis and overall (0.75) or disease-free (p=0.06) survival. The overall and disease-free survival was not statistically significant between the patient groups with absolute monocyte count >0.5x109/l and ≤0.5x109/l. However, we found a moderate correlation between LDH and absolute monocyte count at diagnosis (r=0.499; p=0.015).
Conclusion: The correlation between LDH levels and absolute monocyte count at diagnosis suggests a relation between these two parameters and prognosis.

Keywords: Absolute monocyte count, disease-free survival, mantle Cell Lymphoma, overall survival, prognostic factor