Medicinal Importance, Pharmacological Activity, and Analytical Aspects of Marein in Medicine: An Active Flavonoid With Diverse Biological Potential

Coreopsis tinctoria is planted worldwide including China, Portugal and India. The capitula of Coreopsis tinctoria are used as a functional tea to prevent numerous human health complications, including cardiovascular diseases and diabetes. Marein also called okanin-4'-O-β-D-glucopyranoside is an important phytochemical of chalcone subgroup of polyphenols, found to be present in the flavonoid fraction of Coreopsis tinctoria. In the present paper we have collected all the scientific information of marein and presented in this review article in order to know the therapeutic value of marein in medicine. Scientific information of marein for their biological activities has been searched in Google, Google Scholar, PubMed, Scopus, and Science Direct and collected scientific information of marein were presented here in this review article. All the collected scientific information of marein has been analyzed in the present review paper in order to know the health beneficial aspects of marein. Present paper scientific data described the biological importance and therapeutic potential of marein for their effectiveness in SARS-CoV-2, cancer, hyperglycemia, diabetic encephalopathy, diabetic nephropathy, osteoclastogenesis, pancreatitis and renal fibrosis. Further present paper also described their intestinal absorption, antioxidant, cytoprotective potential with their effect on epidermal growth factor. However the analytical techniques of marein for its separation, isolation and identification of in various samples were also described in the present paper. Present work will be beneficial for all the researchers to know the biological importance and therapeutic potential of marein.

Keywords: Antioxidant, cancer, cytoprotective potential, diabetic encephalopathy, diabetic nephropathy, hyperglyce-mia, marein, osteoclastogenesis, pancreatitis, renal fibrosis, SARS-CoV-2.