Treatment in PFAPA Syndrome: A Review

The most common disease with recurrent fever is PFAPA syndrome, which includes fever, aphthous stomatitis, pharyngitis, and cervical adenitis. Medical treatment (attack treatment, prophylactic treatment) and tonsillectomy are recommended treatments for this disease, and there are corticosteroids that are effective in the management of fever attacks, colchicine for the prophylaxis of febrile attacks, and some drugs whose efficacy has not yet been proven. Tonsillectomy may be an option for some patients. PFAPA syndrome of childhood usually resolves during adolescence. There are also adult-onset and childhood-onset PFAPA syndrome cases.

Keywords: Aphthous stomatitis, corticosteroid, recurrent fever, pharyngitis, PFAPA syndrome