Article
Open Access
Volume 3 · Issue 2 · 2023
pp. 67–69
The Role of Sirtuin 2 in Chemotherapeutic Resistance
Özlem Türelik1, Damla Gül Fındık2
1
Department of Pathology, Bilecik Training and Research Hospital, Bilecik, Türkiye
2
Department of Histology and Embryology, Bilecik Şeyh Edebali University Faculty of Medicine, Bilecik, Türkiye
Abstract
The lack of effective chemotherapy agents and the development of multi-drug resistance in advanced cancers are major encountered issues during treatment phase. The resistance of cancer cells against chemotherapeutic agents may occur as a result of different mechanisms. The identification of molecular pathways involved in drug resistance will yield the occurrence of alternative therapeutic strategies. Sirtuin 2 is one of the NAD-dependent deacetylases. It is involved in carcinogenesis to fulfill oncogenic and tumor-suppressing functions. Therefore, Sirtuin 2 modulation becomes a promising approach in cancer treatments. A better understanding of Sirtuin 2 related pathways is required to provide guidance to alternative cancer treatments. There are several studies about the effects of Sirtuin 2 on various types of cancers in recent years. Within the scope of this review, it is aimed to present the molecular pathways of Sirtuin 2 and its association with chemotherapeutic resistance.
Keywords: Drug resistance, neoplasms, Sirtuin 2
